abstract::Calls to reform medical education recommend explicit training in professional identity formation to promote the development of humanistic, compassionate physicians. The authors report their experience offering The Physician Healer Track, a 500-contact-hour curricula integrated over 4 years, focusing on self-awareness,...
journal_title:Medical education onlinepub_type: 杂志文章
doi:10.1080/10872981.2020.1844394
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Ulcerative colitis (UC) is a recrudescent and chronic inflammatory disease. Artesunate (ART) has shown its anti-inflammatory and antioxidative properties in severe diseases, including UC. OBJECTIVE:The present study investigates the molecular mechanisms for effects of ART on UC, and the role of miR-155 in this...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2020.1867196
更新日期:2021-12-01 00:00:00
abstract::Pattern recognition receptors (PRRs) are responsible for Aspergillus fumigatus recognition by innate immunity and its subsequent immune signaling. The triggering receptor expressed on myeloid cells 1 (TREM1) is a recently characterized pro-inflammatory receptor constitutively expressed on the surface of neutrophils an...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1879471
更新日期:2021-12-01 00:00:00
abstract::The main objective of this study is to provide an overview of the evolution of the medical system in Wallachia between 1840 and 1860 and the very important role of physician Nicolae Gussi (1802-1869), protomedicus of Wallachia between 1840 and 1859, to transform medicine into a modern public service, accessible to the...
journal_title:Acta medico-historica adriatica : AMHApub_type: 传,历史文章,杂志文章
doi:10.31952/amha.18.2.3
更新日期:2021-12-01 00:00:00
abstract::The slowly activating delayed rectifier K+ current (IKs) plays a key role in the repolarization of ventricular action potential in the human heart and is formed by the pore-forming α-subunit encoded by KCNQ1 (Kv7.1) and β-subunit encoded by KCNE1. Evidence suggested that IKs was regulated through protein kinase C (PKC...
journal_title:Channels (Austin, Tex.)pub_type: 杂志文章
doi:10.1080/19336950.2021.1882112
更新日期:2021-12-01 00:00:00
abstract:: Background : Mutations in SCN5A that decrease Na current underlie arrhythmia syndromes such as the Brugada syndrome (BrS). SCN5A in humans has two splice variants, one lacking a glutamine at position 1077 (Q1077del) and one containing Q1077. We investigated the effect of s...
journal_title:Channels (Austin, Tex.)pub_type: 杂志文章
doi:10.1080/19336950.2021.1875645
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:In cancer survivors, chemotherapy-associated adverse neurological effects are described as side effects in non-targeted tissue. We investigated the role of redox-imbalance in neuronal damage by a relative low dose of Docetaxel (DTX). METHODS:The neuroblastoma cells (SH-SY5Y cells) were exposed to DTX at a d...
journal_title:Redox report : communications in free radical researchpub_type: 杂志文章
doi:10.1080/13510002.2021.1884802
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:To minimise the risk of COVID-19 transmission, an ambulant screening protocol for COVID-19 in patients before admission to the hospital was implemented, combining the SARS CoV-2 reverse-transcriptase polymerase chain reaction (RT-PCR) on a nasopharyngeal swab, a chest computed tomography (CT) and assessment ...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1878272
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:Optimal selection of pretransplant conditioning is crucially vital for improving survival and quality-of-life of patients who receive allogeneic hematopoietic cell transplantation (allo-HCT), particularly in those with high-risk diseases. In this study, we evaluated the efficacy and safety of recently-develo...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1881228
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Rotundic acid (RA), a plant-derived pentacyclic triterpene acid, has been reported to possess extensive pharmacological activities. The poor bioavailability limits its further development and potential clinic application. OBJECTIVE:To clarify the potential mechanism for poor oral bioavailability. MATERIALS AN...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1871634
更新日期:2021-12-01 00:00:00
abstract::Global efforts to improve menstrual health and sexual and reproductive health and rights (SRHR) are fundamentally intertwined and share similar goals for improving health and well-being and increasing gender equality. Historically, however, the two fields have operated independently and missed opportunities to build u...
journal_title:Sexual and reproductive health matterspub_type: 杂志文章
doi:10.1080/26410397.2021.1882791
更新日期:2021-12-01 00:00:00
abstract::The outbreaks of hepatitis-hydropericardium syndrome (HPS) caused by the highly pathogenic serotype 4 fowl adenovirus (FAdV-4) have caused a huge economic loss to the poultry industry globally since 2013. Although the Fiber-2 has been identified as a key virulent related factor for FAdV-4, little is known about its mo...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1888458
更新日期:2021-12-01 00:00:00
abstract::The work reported herein describes the synthesis of a new series of anti-inflammatory pyrazolyl thiazolones. In addition to COX-2/15-LOX inhibition, these hybrids exerted their anti-inflammatory actions through novel mechanisms. The most active compounds possessed COX-2 inhibitory activities comparable to celecoxib (I...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1887169
更新日期:2021-12-01 00:00:00
abstract::Background: There is increasing recognition in medical education that greater emphasis must be placed on preparing graduating medical students for their new roles as interns. Few publications in the literature have described transition-to-residency curricula specifically for students interested in pediatrics or pediat...
journal_title:Medical education onlinepub_type: 杂志文章
doi:10.1080/10872981.2021.1892569
更新日期:2021-12-01 00:00:00
abstract::Recently, the prevalence trend of pulmonary fungal infection (PFI) has rapidly increased. Changes in the risk factors for, distributions of underlying diseases associated with and clinical characteristics of some individual PFIs have been reported in the past decade. However, data regarding PFIs remain uncertain. This...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1894902
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Andrographolide (Andro) has a neuroprotective effect and a potential for treating Alzheimer's disease (AD), but the mechanism has not been elucidated. OBJECTIVE:The efficacy of Andro on p62-mediated Kelch-like ECH-associated protein 1(Keap1)-Nuclear factor E2 related factor 2 (Nrf2) pathways in the aluminium m...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1883678
更新日期:2021-12-01 00:00:00
abstract::The study aimed to assess the prevalence and correlates of sexual risk behaviours among adolescents in Mozambique. In the cross-sectional 'Global School-Based Health Survey (GSHS)', 1918 students aged 11-18 years from Mozambique responded to a questionnaire in 2015. More than half (57.4%) of the students ever had sex,...
journal_title:SAHARA J : journal of Social Aspects of HIV/AIDS Research Alliancepub_type: 杂志文章
doi:10.1080/17290376.2020.1858947
更新日期:2021-12-01 00:00:00
abstract::Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a zoo tonic, highly pathogenic virus. The new type of coronavirus with contagious nature spread from Wuhan (China) to the whole world in a very short time and caused the new coronavirus disease (COVID-19). COVID-19 has turned into a global public health c...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章,评审
doi:10.1080/21691401.2021.1890103
更新日期:2021-12-01 00:00:00
abstract:INTRODUCTION:Non-ischaemic heart disease (NIHD) is the underlying pathology in∼20% of all sudden cardiac deaths (SCDs). Heavy drinking is known to be associated with SCD due to ischaemic heart disease, but studies on association of recent alcohol consumption and SCD in patients with NIHD are scarce. We evaluated the bl...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1890204
更新日期:2021-12-01 00:00:00
abstract::With the increase of grape planting years, the base number of pathogenic seedlings and insect population is gradually rising. In addition, the introduction, breeding system and control of seedlings are not standardized and other human factors, the occurrence of Botrytis cinerea(B.cinerea) on grape is becoming more and...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1888578
更新日期:2021-12-01 00:00:00
abstract::Ehrlichia chaffeensis causes human monocytic ehrlichiosis (HME), which is one of the most prevalent, life-threatening emerging infectious zoonoses. The life cycle of E. chaffeensis includes ticks and mammals, in which E. chaffeensis proteins are expressed differentially contributing to bacterial survival and infection...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1899054
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:The purpose of the current study was to determine the performance of contrast-enhanced ultrasound (CEUS) in the assessment of radiofrequency ablation (RFA) of hyperplastic parathyroid glands due to secondary hyperparathyroidism (SHPT). METHODS:Thirty-two patients, each with ≥4 hyperplastic parathyroid gland...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1889601
更新日期:2021-12-01 00:00:00
abstract::Microbial fuel cells (MFC) can use microorganisms to directly convert the chemical energy of organic matter into electrical energy, and generate electrical energy while pollutants degradation. To solve the critical problem of lower power yield of power production, this study selected Saccharomyces cerevisiae, Escheric...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1883280
更新日期:2021-12-01 00:00:00
abstract::This study aimed to utilize cholesterol conjugation of 5-fluorouracil (5-FUC) and liposomal formulas to enhance the partitioning of 5-FU into low density lipoprotein (LDL) to target hepatocellular carcinoma (HCC). Thus, 5-FU and 5-FUCwere loaded into liposomes. Later, the direct loading and transfer of 5-FU, and 5-FUC...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1896202
更新日期:2021-12-01 00:00:00
abstract::Mobile 3D fluoroscopes have become increasingly available in neurosurgical operating rooms. We recently reported its use for imaging cerebral vascular malformations and aneurysms. This study was conducted to evaluate various radiation settings for the imaging of cerebral aneurysms before and after surgical occlusion. ...
journal_title:Computer assisted surgery (Abingdon, England)pub_type: 杂志文章
doi:10.1080/24699322.2021.1894240
更新日期:2021-12-01 00:00:00
abstract::We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were assoc...
journal_title:Emerging microbes & infectionspub_type: 信件
doi:10.1080/22221751.2021.1902755
更新日期:2021-12-01 00:00:00
abstract::Background: Little is known about how younger schoolchildren in a rural setting experience their sense of coherence (SOC), how they think and reason about health and what they perceive as important to achieve health goals. This study aimed to investigate children's SOC and their health perceptions.Method: In this mixe...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2021.1893534
更新日期:2021-12-01 00:00:00
abstract::Bioassay-guided fractionation of the ethyl acetate extract from Teucrium flavum subsp. glaucum, endowed with inhibitory activity towards the HIV-1 reverse transcriptase-associated RNase H function, led to the isolation of salvigenin (1), cirsimaritin (2) and cirsiliol (3) along with the neo-clerodanes teuflavin (4) an...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1887170
更新日期:2021-12-01 00:00:00
abstract::Background: The primary objective of this review was to explore the contribution of oxidative stress to the pathogenesis of genetically-triggered thoracic aortic aneurysm (TAA). Genetically-triggered TAAs manifest substantial variability in onset, progression, and risk of aortic dissection, posing a significant clinic...
journal_title:Redox report : communications in free radical researchpub_type: 杂志文章
doi:10.1080/13510002.2021.1899473
更新日期:2021-12-01 00:00:00
abstract::Malignant melanoma is a life-threatening form of skin cancer with a low response rate to single-agent chemotherapy. Although combined therapies of metformin (MET) and doxorubicin (DOX) are effective in treating a variety of cancers, including breast cancer, their different physicochemical properties and administration...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1898703
更新日期:2021-12-01 00:00:00
abstract::d-Glycero-β-d-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei (BpHldC) is the fourth enzyme in the ADP-l-glycero-β-d-manno-heptose biosynthesis pathway producing a lipopolysaccharide core. Therefore, BpHldC is an anti-melioidosis target. Three ChemBridge compounds purchased from ChemBridge...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1900166
更新日期:2021-12-01 00:00:00
abstract::For Pseudomonas aeruginosa (PA), infection control and appropriate antimicrobial treatment have become important issues. Diagnosis is critical in managing PA infection, but conventional methods are not highly accurate or rapid. We developed a new PA quantification system based on 23S rRNA-targeted reverse transcriptio...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1906164
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:To compare disability changes measured with the Respiratory ICF Maugeri core set on COPD patients, recovering from acute exacerbation with and without hospitalization, submitted to pulmonary rehabilitation (PR). MATERIALS AND METHODS:All COPD inpatients admitted for rehabilitation in 9 Respiratory Units (Jan...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1900592
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:This study sought to investigate the effect of local expression of galectin-3 in the development of stenotic arteriovenous fistula (AVF). METHODS:We collected stenotic venous tissues, adjacent nonstenotic venous tissues, and blood samples from end-stage renal disease (ESRD) patients with AVF stenosis, while ...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1902822
更新日期:2021-12-01 00:00:00
abstract::The underlying molecular mechanisms of intervertebral disc degeneration (IDD) remain unclear. This study aimed to identify the crucial molecules and explore the function of noncoding RNAs and related pathways in IDD. We randomly selected three samples each from an IDD and a spinal cord injury group (control) for RNA-s...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1899533
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Depression and cardiovascular disease (CVD) are major causes of global disease burden that are interrelated through mostly unknown mechanisms. We studied the relationship of melancholic and non-melancholic depressive symptoms with arterial stiffness, an important underlying mechanism of CVD. METHODS:The Hel...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1904277
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Kyeongok-go (KOG) is a traditional mixed herb preparation consisting of Panax ginseng CA Meyer (Araliaceae), Poria cocos Wolf (Polyporaceae), Rehmannia glutinosa (Gaertner) Liboschitz ex Steudel (Orobanchaceae), and honey. Various pharmacological effects of KOG are reported, but the efficacy on respiratory dise...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1892155
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Gamma conglutin (Cγ) from lupine species represents a potential complementary treatment for type 2 diabetes mellitus (T2DM) because of its hypoglycaemic effect. However, its underlying mechanism of action is not fully known. OBJECTIVE:To evaluate whether Cγ from Lupinus rotundiflorus M. E. Jones (Fabaceae) mod...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1893757
更新日期:2021-12-01 00:00:00
abstract::The dysregulation of microRNAs (miRNAs) expression is relevant to the progression of many tumors. As reported, the abnormal expression of miR-1269b is pivotal in certain cancers' progression. This work was designed to study the role and hidden mechanism of miR-1269b in gastric cancer (GC) progression. In this work, we...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1909951
更新日期:2021-12-01 00:00:00
abstract::All-trans retinoic acid (ATRA) is one of essentially active metabolite of vitamin A, and plays an important role in diverse physiological processes, such as cellular growth and function. Renal interstitial fibrosis (RIF) is a common pathological characteristic of chronic renal disease causing end-stage renal disease c...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1910046
更新日期:2021-12-01 00:00:00